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Invitrogen™ XPA Polyclonal Antibody
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Product Code. 16618924
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Quantity:
100 μL
Unit Size:
100µL
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16618924 100 μL 100µL
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Product Code. 16618924 Supplier Invitrogen™ Supplier No. PA5102447

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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total XPA.

The XPA (xeroderma pigmentosumgroup A) protein specifically recognizes the UV-orchemically damaged DNA lesions, and triggers thenucleotide excision repair process. XPA binds to thereplication protein A (RPA) or the excision repaircross complementing 1 protein (ERCC 1). In the absence of nucleotide excision repair persisting (unrepaired) DNA lesions (adducts) may lead to the accumulation of gene mutations and ultimately to cancer. Xeroderma pigmentosum patients have a >2000 fold increased risk to develop skin cancer atsun-exposed areas.
TRUSTED_SUSTAINABILITY

Specifications

Antigen XPA
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene XPA
Gene Accession No. P23025, Q64267
Gene Alias AI573865; DNA repair protein complementing XP-A cells; DNA repair protein complementing XP-A cells homolog; excision repair-controlling; mutant xeroderma pigmentosum complementation group A; xeroderma pigmentosum group A-complementing protein; Xeroderma pigmentosum group A-complementing protein homolog; xeroderma pigmentosum, complementation group A; XP1; XPA; XPA, DNA damage recognition and repair factor; Xpac
Gene Symbols XPA
Host Species Rabbit
Immunogen A synthesized peptide derived from human XPA(Accession P23025), corresponding to amino acid residues H171-K221.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22590, 298074, 7507
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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