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W-54011, MedChemExpress

Product Code. 16447248
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Product Code. 16447248 Supplier Medchem Express Supplier No. HY16992A

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Description

MedChemExpress W-54011 is a potent and orally active non-peptide C5a receptor antagonist. W-54011 inhibits the binding of 125I-labeled C5a to human neutrophils with a Ki value of 2.2 nM. W-54011 also inhibits C5a-induced intracellular Ca2+ mobilization, chemotaxis, and generation of ROS in human neutrophils with IC50s of 3.1 nM, 2.7 nM, and 1.6 nM, respectively.

W-54011 is a potent and orally active non-peptide C5a receptor antagonist. W-54011 inhibits the binding of 125I-labeled C5a to human neutrophils with a Ki value of 2.2 nM. W-54011 also inhibits C5a-induced intracellular Ca2+ mobilization, chemotaxis, and generation of ROS in human neutrophils with IC50s of 3.1 nM, 2.7 nM, and 1.6 nM, respectively.

Specifications

Chemical Name or Material W-54011
CAS 405098-33-1
Color Light Yellow
Purity Grade Notes Research
Molecular Formula C30H37ClN2O2
Quantity 10 mg
Solubility Information DMSO : ≥ 28 mg/mL (56.79 mM)
SMILES O=C(C1CCCC2=C1C=C(OC)C=C2)N(CC3=CC=C(N(C)C)C=C3)C4=CC=C(C(C)C)C=C4.[H]Cl
Molecular Weight (g/mol) 493.08
Formula Weight 493.08
Percent Purity 98.0%
Grade Research
Physical Form Solid
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