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TYMS Monoclonal Antibody (OTI2C3), TrueMAB™, OriGene
Mouse Monoclonal Antibody
Brand: Origene Technologies TA801701
This item is not returnable.
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Description
Thymidylate Synthase (TS) (EC 2.1.1.45) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.Specifications
| TYMS | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 1% BSA, 50% glycerol and 0.02% sodium azide | |
| P04818 | |
| TYMS | |
| Full length human recombit protein of human TYMS produced in E.coli. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG2a |
| Immunohistochemistry (Paraffin), Western Blot | |
| OTI2C3 | |
| Unconjugated | |
| TYMS | |
| HST422, TMS, TS | |
| Mouse | |
| Affinity Chromatography | |
| RUO | |
| 7298 | |
| -20° C, Avoid Freeze/Thaw Cycles | |
| Liquid |
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