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Invitrogen™ TMEM66 Polyclonal Antibody
Description
Immunogen sequence: YSPPPYSEYPP FSHRYQRFTN SAGPPPPGFK SEFTGPQNTG HGATSGFGSA FT Highest antigen sequence identity to the following orthologs - mouse 75%, rat 70%.
Saraf encodes a protein that is a negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the de-oligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions.
Specifications
Specifications
| Antigen | TMEM66 |
| Applications | Immunocytochemistry |
| Classification | Polyclonal |
| Concentration | 0.2 mg/mL |
| Conjugate | Unconjugated |
| Formulation | PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 |
| Gene | SARAF |
| Gene Accession No. | Q96BY9 |
| Gene Alias | 1810045K07Rik; arrestin-E; FOAP-7; HBV XAg-transactivated protein 3; HBV X-transactivated gene 3 protein; HSPC035; NPD003; Protein FOAP-7; PSEC0019; Saraf; SARAF long isoform; SARAF short isoform; SOCE-associated regulatory factor; store-operated calcium entry associated regulatory factor; store-operated calcium entry-associated regulatory factor; testicular secretory protein Li 59; TMEM66; Transmembrane protein 66; UNQ1967/PRO4499; XTP3 |
| Gene Symbols | SARAF |
| Show More |
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