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  8. Tirabrutinib hydrochloride, MedChemExpress

Tirabrutinib hydrochloride, MedChemExpress

Product Code. 16499357
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Product Code. 16499357

Brand: Medchem Express HY15771A

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Description

MedChemExpress Tirabrutinib (ONO-4059) hydrochloride is an orally active Bruton’s Tyrosine Kinase (BTK) inhibitor (can cross the blood-brain barrier (BBB)), with an IC50 of 6.8 nM. Tirabrutinib hydrochloride irreversibly and covalently binds to BTK and inhibits aberrant B cell receptor signaling. Tirabrutinib hydrochloride can be used in studies of autoimmune diseases and hematological malignancies.

Tirabrutinib (ONO-4059) hydrochloride is an orally active Bruton’s Tyrosine Kinase (BTK) inhibitor (can cross the blood-brain barrier (BBB)), with an IC50 of 6.8 nM. Tirabrutinib hydrochloride irreversibly and covalently binds to BTK and inhibits aberrant B cell receptor signaling. Tirabrutinib hydrochloride can be used in studies of autoimmune diseases and hematological malignancies.

Specifications

Chemical Name or Material Tirabrutinib hydrochloride
CAS 1439901-97-9
Color White
Purity Grade Notes Research
Molecular Formula C25H23ClN6O3
Quantity 5 mg
Synonym ONO-4059 hydrochlorideGS-4059 hydrochloride
Solubility Information DMSO : 100 mg/mL (203.69 mM; Need ultrasonic)
SMILES O=C1N(C2=CC=C(OC3=CC=CC=C3)C=C2)C4=C(N)N=CN=C4N1[C@H]5CN(C(C#CC)=O)CC5.[H]Cl
Molecular Weight (g/mol) 490.94
Formula Weight 490.94
Percent Purity 98.0%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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