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  6. Invitrogen™ TCR V beta 13 Monoclonal Antibody (MR12-3), APC, eBioscience™

Invitrogen™ TCR V beta 13 Monoclonal Antibody (MR12-3), APC, eBioscience™
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Product Code. 15528136
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Quantity:
100 μg
Unit Size:
100µg
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15528136 100 μg 100µg
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Product Code. 15528136 Supplier Invitrogen™ Supplier No. 17579782

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Description

Mouse Monoclonal Antibody

Description: This MR12-3 monoclonal antibody reacts with the T cell receptor (TCR) V beta 13 chain. Composed of an alpha and beta chain, TCR specificity is typically determined by Va, Ja, Vb, Db, and Jb gene rearrangement. The MR12-3 antibody recognizes the V beta 13 chains on T cells from mouse strains with the b haplotype of the Tcrb gene, including C57BL/6, B10, and C3H. V beta 13+ T cells are deleted in mouse strains with the a (e.g., SJL) and c (e.g., RIIIS/J) haplotypes. The MR12-3 monoclonal antibody has been reported to have blocking activity. Applications Reported: This MR12-3 antibody has been reported for use in flow cytometric analysis. Applications Tested: This MR12-3 antibody has been tested by flow cytometric analysis of mouse lymph node cells. This can be used at less than or equal to 0.5 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser. Filtration: 0.2 μm post-manufacturing filtered.

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease. Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.
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Specifications

Antigen TCR V beta 13
Applications Flow Cytometry
Classification Monoclonal
Clone MR12-3
Concentration 0.2 mg/mL
Conjugate APC
Formulation PBS with 0.09% sodium azide; pH 7.2
Gene Alias TCR V beta13; TCRV beta 13; TCRV beta13; Vb13; Vbeta13
Host Species Mouse
Purification Method Affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Mouse
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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