Applied Biosystems™ TaqMan™ Array Human MAPK Pathways

These 96-well plates are pre-configured with the most appropriate TaqMan™ Gene Expression Assays for a specific biological process, pathway, or disease state. Each plate contains predefined assays and endogenous controls dried-down in the wells, ready for accurate assessment of an entire gene signature in one simple experiment.

The panel of assays in the TaqMan™ Array 96-well Human MAP Kinase Pathways Plate targets genes from the four major groups of mammalian MAPKs: 1) ERKs (Extracellular signal-Regulated Kinases); 2) p38 MAPKs; 3) JNKs (c-Jun NH2-terminal Kinases); and 4) ERK5 (or BMK cascades). Genes from the MAP2K (MAPKK), MAP3K (MAPKKK), and dual-specificity protein kinase MAPKK (DUSP) groups are also on the panel. Other groups of kinases in this panel include: cyclin dependent kinase (CDK), MAP kinase interacting serine⁄threonine kinase (MNK), p21 activated kinases (PAK), and ribosomal S6 kinases (RSK). Several MAPK targets including genes associated with signal transduction, transcription regulation, cell cycle regulation and cancer are also included.