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  8. TAK-960, MedChemExpress

TAK-960, MedChemExpress

Product Code. p-200099495
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Product Code. 16488917

Brand: Medchem Express HY15160

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Description

MedChemExpress TAK-960 is an orally available, selective inhibitor of polo-like kinase 1 (PLK1), with an IC50 of 0.8 nM. TAK-960 also shows inhibitory activities against PLK2 and PLK3, with IC50s of 16.9 and 50.2 nM, respectively. TAK-960 inhibits proliferation of multiple cancer cell lines and exhibits significant efficacy against multiple tumor xenografts.

TAK-960 is an orally available, selective inhibitor of polo-like kinase 1 (PLK1), with an IC50 of 0.8 nM. TAK-960 also shows inhibitory activities against PLK2 and PLK3, with IC50s of 16.9 and 50.2 nM, respectively. TAK-960 inhibits proliferation of multiple cancer cell lines and exhibits significant efficacy against multiple tumor xenografts.

Specifications

Chemical Name or Material TAK-960
CAS 1137868-52-0
Color White
Purity Grade Notes Research
Molecular Formula C27H34F3N7O3
Quantity 5 mg
Solubility Information DMSO : 16.67 mg/mL (29.68 mM; ultrasonic and warming and heat to 60°C)
SMILES O=C(NC1CCN(C)CC1)C2=CC(OC)=C(NC3=NC=C(N4C)C(N(C5CCCC5)CC(F)(F)C4=O)=N3)C=C2F
Molecular Weight (g/mol) 561.6
Formula Weight 561.6
Percent Purity 95.44%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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