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TAK-243, MedChemExpress

Product Code. 16465777
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Product Code. 16465777 Supplier Medchem Express Supplier No. HY100487

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Description

MedChemExpress TAK-243 (MLN7243) is a first-in-class, selective ubiquitin activating enzyme, UAE (UBA1) inhibitor (IC50=1 nM), which blocks ubiquitin conjugation, disrupting monoubiquitin signaling as well as global protein ubiquitination. TAK-243 (MLN7243) induces endoplasmic reticulum (ER) stress, abrogates NF-κB pathway activation and promotes apoptosis.

TAK-243 (MLN7243) is a first-in-class, selective ubiquitin activating enzyme, UAE (UBA1) inhibitor (IC50=1 nM), which blocks ubiquitin conjugation, disrupting monoubiquitin signaling as well as global protein ubiquitination. TAK-243 (MLN7243) induces endoplasmic reticulum (ER) stress, abrogates NF-κB pathway activation and promotes apoptosis.

Specifications

Chemical Name or Material TAK-243
Physical Form Solid
CAS 1450833-55-2
Color Off-White
Quantity 5 mg
Purity Grade Notes Research
Molecular Formula C19H20F3N5O5S2
For Use With (Application) Cancer-programmed cell death
Synonym MLN7243
Solubility Information DMSO : 50 mg/mL (96.24 mM; Need ultrasonic) ∣H2O : 1 mg/mL (1.92 mM; Need ultrasonic)
SMILES O=S(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](NC2=CC=NC3=CC(C4=CC=CC(SC(F)(F)F)=C4)=NN23)C1)(N)=O
Molecular Weight (g/mol) 519.52
Formula Weight 519.52
Percent Purity 98.0%
Grade Research
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Research purposes only

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