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Invitrogen™ SOCS1 Recombinant Rabbit Monoclonal Antibody (6C6W1)
Rabbit Recombinant Monoclonal Antibody
176.00 EUR - 436.00 EUR
Specifications
| Antigen | SOCS1 |
|---|---|
| Clone | 6C6W1 |
| Concentration | 1.00 mg/mL |
| Content And Storage | -20°C, Avoid Freeze/Thaw Cycles |
| Applications | ELISA, Immunohistochemistry (Paraffin) |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
30282851
|
Invitrogen™
MA558005 |
20 μL |
176.00 EUR
20µL |
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|
30283561
|
Invitrogen™
MA558006 |
100 μL |
436.00 EUR
100µL |
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Description
Immunogen sequence: MVAHNQVAAD NAVSTAAEPR RRPEPSSSSS SSPAAPARPR PCPAVPAPAP GDTHFRTFRS HADYRRITRA SALLDACGFY WGPLSVHGAH ERLRAEPVGT.
The Suppressor of cytokine signaling (SOCS) and cytokine-inducible SH2 proteins are a family of intracellular proteins which regulate the immune cell responses to cytokines. SOCS1 acts to suppress dendritic cell (DC) as well as T cell hyperactivation following cytokine signaling by inhibiting JAK tyrosine kinase, a kinase necessary for type I and II cytokine receptors to initiate signaling, by directly binding to the catalytic domain of the kinase. SOCS1 also possesses E3 ubiquitin protein ligase activity that results in the polyubiquitination of its target proteins and subsequent degradation by the proteosome. It is through this method that SOCS1 negatively regulates signaling by Toll-like receptors TLR2 and TLR4 by mediating the degradation of the TLR signaling adaptor protein TIRAP.Specifications
| SOCS1 | |
| 1.00 mg/mL | |
| ELISA, Immunohistochemistry (Paraffin) | |
| Unconjugated | |
| Rabbit | |
| RUO | |
| PBS with 0.05% BSA, 50% glycerol and 0.09% sodium azide; pH 7.3 | |
| O15524, O35716, Q9QX78 | |
| 12703, 252971, 8651 | |
| A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SOCS1 (NP_003736.1). | |
| Antibody |
| 6C6W1 | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Recombinant Monoclonal | |
| Liquid | |
| IgG | |
| Human, Mouse, Rat | |
| Socs1 | |
| CIS1; Cish1; Cish7; cytokine inducible SH2-containing protein 1; cytokine inducible SH2-containing protein 7; cytokine-inducible SH2 protein 1; JAB; JAK binding protein; JAK2-binding protein; JAK-binding protein; Socs1; SOCS-1; SSI1; SSI-1; STAT induced SH3 protein 1; STAT-induced STAT inhibitor 1; Suppressor of cytokine signaling 1; Tec-interacting protein 3; TIP3; TIP-3 | |
| Socs1 | |
| Primary | |
| Affinity chromatography |
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