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Invitrogen™ SNAP alpha Recombinant Rabbit Monoclonal Antibody (7Z6F6)
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Description
Positive Samples: HepG2, A-549, Mouse brain, Rat brain Immunogen sequence: SAKDYFFKAA LCHFCIDMLN AKLAVQKYEE LFPAFSDSRE CKLMKKLLEA HEEQNVDSYT ESVKEYDSIS RLDQWLTTML LRIKKTIQGD EEDLR.
SNAPs (soluble NSF attachment proteins), acting in concert with SNAREs (SNAP receptors) and the N-ethylmaleimide-sensitive fusion protein (NSF) are required for the fusion of transport vesicles to their target membranes in synaptic transmission, intra-Golgi transport, endosome-to-endosome fusion and transcytotic vesicles-to-plasma membrane transport. Vesicle-to-target membrane docking (initial contact) occurs when the vesicle SNARE binds to its cognate target membrane SNARE. a-SNAP (or b-SNAP in brain) then binds to this docking complex and mediates the binding of NSF and thus the formation of a 20S fusion particle. It is thought that, once NSF is bound, ATP hydrolysis by NSF initiates the fusion process.
Specifications
Specifications
| Antigen | SNAP alpha |
| Applications | ELISA, Western Blot |
| Classification | Recombinant Monoclonal |
| Clone | 7Z6F6 |
| Concentration | 1.31 mg/mL |
| Conjugate | Unconjugated |
| Formulation | PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3 |
| Gene | NAPA |
| Gene Accession No. | P54920, P54921, Q9DB05 |
| Gene Alias | 1500039N14Rik; alpha snap; alpha soluble NSF attachment protein; alpha-SNAP; Alpha-soluble NSF attachment protein; a-SNAP; AW209189; hydrocephaly with hop gait; hyh; Napa; N-ethylmaleimide sensitive fusion protein attachment protein alpha; N-ethylmaleimide-sensitive factor attachment protein alpha; N-ethylmaleimide-sensitive factor attachment protein, alpha; NSF attachment protein alpha; RA81; Snap; SNAPA; SNAP-alpha; SNARE |
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