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Shikonin, MedChemExpress

Product Code. 16483906
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Product Code. 16483906 Supplier Medchem Express Supplier No. HYN0822

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Description

MedChemExpress Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC50 of 6.5 μM. Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor and can also inhibit TNF-α and NF-κB pathway. Shikonin decreases exosome secretion through the inhibition of glycolysis. Shikonin inhibits AIM2 inflammasome activation.

Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC50 of 6.5 μM. Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor and can also inhibit TNF-α and NF-κB pathway. Shikonin decreases exosome secretion through the inhibition of glycolysis. Shikonin inhibits AIM2 inflammasome activation.

Specifications

Chemical Name or Material Shikonin
CAS 517-89-5
Color Dark Brown
Purity Grade Notes Research
Molecular Formula C16H16O5
Quantity 25 mg
Synonym C.I. 75535 Isoarnebin 4
Solubility Information DMSO : 25 mg/mL (86.72 mM; ultrasonic and warming and heat to 60°C)
SMILES O=C1C([C@H](O)C/C=C(C)/C)=CC(C2=C1C(O)=CC=C2O)=O
Molecular Weight (g/mol) 288.3
Formula Weight 288.3
Percent Purity 98.09%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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