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SHARPIN Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
145.00 EUR - 410.00 EUR
Specifications
| Antigen | SHARPIN |
|---|---|
| Concentration | 0.33 mg/mL |
| Applications | Immunohistochemistry (Paraffin), Western Blot, Immunoprecipitation |
| Classification | Polyclonal |
| Conjugate | Unconjugated |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
16803364
|
Proteintech
14626-1-AP-20UL |
20 μL |
145.00 EUR
20µL |
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|
16893354
|
Proteintech
14626-1-AP-150UL |
150 μL |
410.00 EUR
150µL |
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Description
Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.Specifications
| SHARPIN | |
| Immunohistochemistry (Paraffin), Western Blot, Immunoprecipitation | |
| Unconjugated | |
| Rabbit | |
| Rat, Human, Mouse | |
| Q91WA6, Q9EQL9, Q9H0F6 | |
| 106025, 81858, 81859 | |
| SHARPIN Fusion Protein Ag6201 | |
| Primary | |
| -20°C | |
| SHARPIN |
| 0.33 mg/mL | |
| Polyclonal | |
| Liquid | |
| RUO | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
| hSIPL1, SHARPIN, SIPL1 | |
| SHARPIN | |
| IgG | |
| Antigen Affinity Chromatography | |
| Antibody |
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