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Invitrogen™ SF1 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA536103
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Description
This antibody detects endogenous protein at a molecular weight of 68 kDa. Purity is >95% by SDS-PAGE.
Splicing factor 1 is a nuclear pre-mRNA splicing factor. The protein specifically recognizes the intron branch point sequence at the 3' splice site, together with the large subunit of U2 auxiliary factor (U2AF), and is required for the early stages of spliceosome assembly. It also plays a role in nuclear pre-mRNA retention and transcriptional repression. The protein contains an N-terminal U2AF ligand motif, a central hnRNP K homology motif and quaking 2 region which bind a key branch-site adenosine within the branch point sequence, a zinc knuckles domain, and a C-terminal proline-rich domain. Alternative splicing results in multiple transcript variants.
Specifications
| SF1 | |
| Polyclonal | |
| Unconjugated | |
| SF1 | |
| BBP; D11S636; M ZFM1; Mammalian branch point-binding protein; MBBP; MZFM; SF; SF1; Splicing factor 1; transcription factor ZFM1; WBP4; wu:fc09f06; ZCCHC25; ZFM1; Zfp162; Zinc finger gene in MEN1 locus; zinc finger protein 162; ZNF162 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 117855, 22668, 7536 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
| 1 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.2 | |
| Q15637, Q64213 | |
| SF1 | |
| Synthetic peptide corresponding to amino acids 45-98 of human SF1. | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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