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  8. SEL120-34A monohydrochloride, MedChemExpress

SEL120-34A monohydrochloride, MedChemExpress

Product Code. 16465326
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Product Code. 16465326 Supplier Medchem Express Supplier No. HY111388A

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Description

MedChemExpress SEL120-34A monohydrochloride is an ATP-competitive and selective CDK8 inhibitor, inhibits kinase activities of CDK8/CycC and CDK19/CycC complexes with IC50s of 4.4 nM and 10.4 nM, respectively, with a Kd of 3 nM for CDK8.

SEL120-34A monohydrochloride weakly inhibits CDK9 (calculated IC50=1070 nM), but shows no obvious activity against CDK1, 2, 4, 6, 5, 7. SEL120-34A monohydrochloride inhibits phosphorylation of STAT1 S727 and STAT5 S726. Has anti-tumor activity.

Specifications

Chemical Name or Material SEL120-34A monohydrochloride
Color Off-White
Purity Grade Notes Research
Molecular Formula C15H19Br2ClN4
Quantity 100 mg
Solubility Information H2O : 50 mg/mL (110.96 mM; Need ultrasonic) ∣DMSO : 16.67 mg/mL (37.00 mM; ultrasonic and warming and heat to 60°C)
SMILES CC1=C2C3=C(C(Br)=C1Br)CCCN3C(N4CCNCC4)=N2.Cl
Molecular Weight (g/mol) 450.6
Formula Weight 450.6
Percent Purity 98.51%
Grade Research
Physical Form Powder
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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