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Rigosertib, MedChemExpress

Product Code. 16484938
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Product Code. 16484938

Brand: Medchem Express HY12037A

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Description

MedChemExpress Rigosertib (ON-01910) is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition the PI3 kinase/Akt pathway, promots the phosphorylation of histone H2AX and induces G2/M arrest in cell cycle. Rigosertib is a selective and non-ATP-competitive inhibitor of PLK1 with an IC50 of 9 nM.

Rigosertib (ON-01910) is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition the PI3 kinase/Akt pathway, promots the phosphorylation of histone H2AX and induces G2/M arrest in cell cycle. Rigosertib is a selective and non-ATP-competitive inhibitor of PLK1 with an IC50 of 9 nM.

Specifications

Chemical Name or Material Rigosertib
CAS 592542-59-1
Color Yellow
Purity Grade Notes Research
Molecular Formula C21H25NO8S
Quantity 10 mg
Synonym ON-01910
Solubility Information DMSO : 75 mg/mL (166.12 mM; Need ultrasonic)
SMILES COC1=CC=C(C=C1NCC(O)=O)CS(/C=C/C2=C(C=C(C=C2OC)OC)OC)(=O)=O.[(E)]
Molecular Weight (g/mol) 451.49
Formula Weight 451.49
Percent Purity 98.0%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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