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  4. Invitrogen™ Human RET [M918T], GST Tag, His Tag Recombinant Protein

Invitrogen™ Human RET [M918T], GST Tag, His Tag Recombinant Protein

Product Code. 15448883
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15448883 100 μg 100µg
15438883 10 μg 10µg
15458883 1 mg 1mg
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Product Code. 15448883 Supplier Invitrogen™ Supplier No. PV6218

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Description

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Human RET M918T, C-terminal fragment, amino acids H658-S1114 (as in NCBI/Protein entry NP_066124.1) with a M918T mutation, N-terminal GST-HIS6 fusion protein with a 3C cleavage site, expressed in Sf9 insect cells. , Validated in LanthaScreen™ Kinase Binding Assay, Protocols available for simple use and optimized performance, Multiple pack sizes available for convenient use Related Product: LanthaScreen™ Eu Kinase Binding Assay Protein Form: Recombinant

RET is a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases which are cell-surface molecules that transduce signals for cell growth and differentiation. RET plays a crucial role in neural crest development, can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in the RET gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for the RET gene. Additional transcript variants have been described for RET but their biological validity has not been confirmed.
TRUSTED_SUSTAINABILITY

Specifications

Concentration See Label
For Use With (Application) Kinase Assay
Formulation 50 mM HEPES with 100 mM NaCl, 15 mM glutathione, 20% glycerol, 5 mM DTT and no preservative; pH 7.5
Molecular Weight (g/mol) 80.4 kDa
Name Human RET [M918T], GST Tag, His Tag
Quantity 100 μg
Common Name RET (M918T Mutant)
Protein Length 658-1114
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag GST-tag, His-tag
Content And Storage -80°C, Avoid Freeze/Thaw Cycles
Expression System Baculovirus
Form Liquid
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