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  8. Ralimetinib dimesylate, MedChemExpress

Ralimetinib dimesylate, MedChemExpress

Product Code. 16495578
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Product Code. 16495578

Brand: Medchem Express HY13241

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Description

MedChemExpress Ralimetinib dimesylate (LY2228820 dimesylate) is a selective, ATP-competitive inhibitor of p38 MAPK α/β with IC50s of 5.3 and 3.2 nM, respectively. Ralimetinib (LY2228820) selectively inhibits phosphorylation of MK2 (Thr334), with no effect on phosphorylation of p38a MAPK, JNK, ERK1/2, c-Jun, ATF2, or c-Myc.

Ralimetinib dimesylate (LY2228820 dimesylate) is a selective, ATP-competitive inhibitor of p38 MAPK α/β with IC50s of 5.3 and 3.2 nM, respectively. Ralimetinib (LY2228820) selectively inhibits phosphorylation of MK2 (Thr334), with no effect on phosphorylation of p38a MAPK, JNK, ERK1/2, c-Jun, ATF2, or c-Myc.

Specifications

Chemical Name or Material Ralimetinib dimesylate
CAS 862507-23-1
Color Yellow
Purity Grade Notes Research
Molecular Formula C26H37FN6O6S2
Quantity 10 mg
Synonym LY2228820 dimesylate
Solubility Information DMSO : 61 mg/mL (99.55 mM; Need ultrasonic and warming)
SMILES FC1=CC=C(C=C1)C2=C(NC(C(C)(C)C)=N2)C3=NC4=C(C=C3)N=C(N)N4CC(C)(C)C.OS(C)(=O)=O.OS(C)(=O)=O
Molecular Weight (g/mol) 612.74
Formula Weight 612.74
Percent Purity 96.97%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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