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Eurofins DiscoverX Raf-1 Protein, Active

Product Code. 17310164
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10 μg
250 μg
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250µg
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17310164 250 μg 250µg
17300164 10 μg 10µg
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Product Code. 17310164 Supplier Eurofins DiscoverX Supplier No. 14352M

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Description

Active, N-terminal GST-tagged recombinant human Raf-1 residues 306-end, containing the mutations Y340D and Y341D, for use in Kinase Assays.

Raf-1 is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.

EMBL X03484

Specifications

Formulation mg/mL of enzyme in 50 mM Tris/HCl, pH 7.5, 150 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.
Molecular Weight (g/mol) 65 kDa
Quantity 250 μg
Species Human
Recombinant Recombinant
Protein Tag N-terminal GST
Expression System Recombinant enzyme expressed in Sf21 insect cells
Protein Form Truncated
Purity or Quality Grade ≥60%
Protein Raf-1 (truncated), active
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