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TK2 Rabbit anti-Human, Mouse, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of TK2.

Brand:  Abnova PAB4599.400uL

Product Code. 16059137

  • 391.00 EUR / 400µL

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Description

Description

The mitochondrial deoxyribonucleotide (dNTP) pool is separated from the cytosolic pool because the mitochondria inner membrane is impermeable to charged molecules. The mitochondrial pool is maintained by either import of cytosolic dNTPs through dedicated transporters or by salvaging deoxynucleosides within the mitochondria; apparently, enzymes of the de novo dNTP synthesis pathway are not present in the mitochondria. In nonreplicating cells, where cytosolic dNTP synthesis is downregulated, mtDNA synthesis depends solely on the mitochondrial salvage pathway enzymes, the deoxyribonucleoside kinases. Two of the 4 human deoxyribonucleoside kinases, deoxyguanosine kinase (DGK) and thymidine kinase-2, are expressed in mitochondria. Human DGK, encoded by the DGUOK gene (MIM 601465), efficiently phosphorylates deoxyguanosine and deoxyadenosine, whereas TK2 phosphorylates deoxythymidine, deoxycytidine, and deoxyuridine. Thymidine kinase-2 (TK2) is a deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine, and also phosphorylates antiviral and anticancer nucleoside analogs.[supplied by OMIM

Specifications

Specifications

TK2
Polyclonal
Rabbit polyclonal antibody raised against synthetic peptide of TK2.
In PBS (0.09% sodium azide)
TK2
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human TK2.
400 μL
Primary
Human, Mouse
Liquid
ELISA, Western Blot
Unconjugated
ELISA (1:1000) Western Blot (1:100-500) The optimal working dilution should be determined by the end user.
TK2
Rabbit
Protein G purification
RUO
7084
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
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