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Invitrogen™ PSEN2 Polyclonal Antibody

Product Code. 30535252
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Quantity:
100 μg
Unit Size:
100µg
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30535252 100 μg 100µg
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Product Code. 30535252 Supplier Invitrogen™ Supplier No. PA5148501

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Description

Goat Polyclonal Antibody

Reconstitute at 0.2 mg/mL in sterile PBS.

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PSEN2
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with trehalose and no preservative
Gene PSEN2
Gene Accession No. P49810
Gene Alias AD3L; AD3LP; AD4; Ad4h; AD5; Alg3; ALG-3; Alzheimer disease 4; CMD1V; E5-1; presenilin 2; presenilin-2; Presenilin-2 CTF subunit; Presenilin-2 NTF subunit; PS2; Ps-2; PSEN 2; PSEN2; Psnl2; STM2; STM-2
Gene Symbols PSEN2
Host Species Goat
Immunogen E. coli-derived recombinant human Presenilin-2, Leu2-Thr80.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5664
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Lyophilized
Isotype IgG
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