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Invitrogen™ Pokemon (LRF) Monoclonal Antibody (13E9), eFluor™ 660, eBioscience™
Armenian Hamster Monoclonal Antibody
221.00 EUR
Specifications
| Antigen | Pokemon (LRF) |
|---|---|
| Clone | 13E9 |
| Concentration | 0.2 mg/mL |
| Content And Storage | 4°C, store in dark, DO NOT FREEZE! |
| Applications | Immunohistochemistry (Paraffin), Immunocytochemistry |
Description
Description: This monoclonal antibody reacts with human Leukemia/lymphoma-related factor (LRF). This 65-kDa protein is also known as POKEMON, FBI-1, and Zbtb7a. LRF is a member of the POK family of transcriptional repressors, and is expressed in hematopoietic stem cells, T and B lymphocytes, macrophages, and erythroid cells. This protein is also highly expressed in human non-Hodgkin's lymphoma tissues and diffuse large B-cell lymphomas, demonstrating its prominent role in oncogenic transformation. Studies have demonstrated that LRF is also involved in B cell lineage commitment and development by opposing Notch signaling. Moreover, LRF is critical for erythroid terminal differentiation in the bone marrow by inhibiting Bim-mediated apoptosis. Finally, LRF interacts with Bcl-6 in germinal center B cells. Applications Reported: This 13E9 antibody has been reported for use in immunohistochemical staining of formalin-fixed paraffin embedded tissue sections, and immunocytochemistry. Applications Tested: This 13E9 antibody has been tested by immunohistochemistry on human FFPE tissue using high pH antigen retrieval and can be used at less than or equal to 5 μg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. eFluor™ 660 is a replacement for Alexa Fluor™ 647. eFluor™ 660 emits at 659 nm and is excited with the red laser (633 nm). Please make sure that your instrument is capable of detecting this f...
Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals. Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3'.Specifications
| Pokemon (LRF) | |
| 0.2 mg/mL | |
| Immunohistochemistry (Paraffin), Immunocytochemistry | |
| eFluor 660 | |
| Armenian Hamster | |
| RUO | |
| PBS with 0.09% sodium azide; pH 7.2 | |
| O95365 | |
| 51341 | |
| Primary | |
| Affinity chromatography |
| 13E9 | |
| 4°C, store in dark, DO NOT FREEZE! | |
| Monoclonal | |
| Liquid | |
| IgG | |
| Human | |
| ZBTB7A | |
| 9030619K07Rik; 9130006G12Rik; AI452336; cLRF; DKFZp547O146; factor binding IST protein 1; Factor that binds to inducer of short transcripts protein 1; FBI1; FBI-1; HIV-1 1st-binding protein 1; HIV-1 inducer of short transcripts binding protein; leukemia/lymohoma related factor cLRF; leukemia/lymphoma related factor; leukemia/lymphoma related factor cLRF; leukemia/lymphoma-related factor; LRF; lymphoma related factor; MGC99631; Oczf; Osteoclast-derived zinc finger protein; POK erythroid myeloid ontogenic factor; Pokemon; POZ and Krueppel erythroid myeloid ontogenic factor; TIP21; TTF-I-interacting peptide 21; Zbtb7; ZBTB7A; zi; zinc finger and BTB domain containing 7a; zinc finger and BTB domain containing 7A, HIV-1 inducer of short transcripts binding protein; zinc finger and BTB domain-containing protein 7A; Zinc finger protein 857A; ZNF857A | |
| ZBTB7A | |
| Antibody |
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