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Podoplanin Rat anti-Human, APC, Clone: NZ-1.3, eBioscience™

Rat Monoclonal Antibody

126.00 EUR - 278.00 EUR

Specifications

Antigen Podoplanin
Clone NZ-1.3
Target Species Human
Conjugate APC
Isotype IgG2a
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15548246 View Documents Affymetrix eBioscience
17-9381-42
100 Tests 278.00 EUR
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15538246 View Documents Affymetrix eBioscience
17-9381-41
25 Tests 126.00 EUR
25 tests View alternative products
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In Stock 2
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Description

Description

Podoplanin (PDPN, T1A, gp38, Aggrus) is a mucin type-1 glycoprotein with a 40-43 kDa molecular weight. Podoplanin is expressed in many tumors and normal cells, especially lymphatic epithelial cells and follicular DCs. Podoplanin localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes. Podoplanin appears to serve as a ligand for CLEC-2 and expression is positively correlated with tumors expressing greater invasive and metastatic potential. Podoplanin is directly involved in cell migration, aids metastases formation and tumor cell invasion of tissue. Further, it has also been determined that podoplanin expression is induced through Src activation of Cas and, recently, there are indications of podoplanin presence on Th17 cells. Initial studies below indicate the presence of podoplanin on a small but distinct population of CD4+ cells from human PBMC. Dysfunction of the podoplanin protein has been linked to diseases such as lymphangioma and subglottis neoplasm. Podoplanin has also been proposed as a marker for lung injury due to the physiological function of the protein.
Specifications

Specifications

Podoplanin
Human
IgG2a
Monoclonal
Liquid
Antibody
4° C, store in dark, DO NOT FREEZE!
NZ-1.3
APC
Flow Cytometry
Primary
Monoclonal
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
RUO

For Research Use Only.