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Invitrogen™ PI3K p85 alpha Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA529220
This item is not returnable.
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Description
Recommended positive controls: 293T, Jurkat, K562, THP-1, Neuro 2A, C8D30, NIH-3T3, Raw264.7, C2C12, PC-12, Rat2. Predicted reactivity: Mouse (89%), Rat (87%), Rhesus Monkey (99%), Bovine (94%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Phosphatidylinositol 3-kinase (PIK3) is a signaling protein that phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. Signaling is initiated when upstream tyrosine kinase receptors or G protein coupled receptors are bound by their ligands. It binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. During insulin stimulation, it also binds to IRS-1. Mutations in the gene can result in Agammaglobulinemia 7, SHORT syndrome, or Immunodeficiency 36.
Specifications
| PI3K p85 alpha | |
| Polyclonal | |
| Unconjugated | |
| PIK3R1 | |
| AGM7; GRB1; IMD36; p50alpha; p55alpha; p55-GAMMA; p55PIK; p85; p85alpha; p85-ALPHA; phosphatidylinositol 3-kinase; phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma; phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; Phosphatidylinositol 3-kinase regulatory subunit alpha; phosphatidylinositol 3-kinase regulatory subunit gamma; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha); phosphatidylinositol 3-kinase-associated p-85 alpha; Phosphoinositide 3-kinase p85 (other splicing variants: p55 and p50); Phosphoinositide 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha); phosphoinositide-3-kinase regulatory subunit; phosphoinositide-3-kinase regulatory subunit 1; phosphoinositide-3-kinase regulatory subunit alpha; phosphoinositide-3-kinase, regulatory subunit 1 (alpha); phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha); phosphoinositide-3-kinase, regulatory subunit, polypeptide 1 (p85 alpha); PI3K; PI3K regulatory subunit alpha; PI3K regulatory subunit gamma; PI3KA; PI3-kinase p85 subunit alpha; PI3-kinase p85-subunit alpha; PI3-kinase regulatory subunit alpha; PI3-kinase regulatory subunit gamma; PI3-kinase subunit p55-gamma; PI3-kinase subunit p85-alpha; Pik3r1; polypeptide 1 p85 alpha; ptdIns-3-kinase p85-alpha; ptdIns-3-kinase regulatory subunit alpha; PtdIns-3-kinase regulatory subunit p85-al; ptdIns-3-kinase regulatory subunit p85-alpha; RP4-533D7.2 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 18708, 25513, 5295 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot | |
| 1.46 mg/mL | |
| PBS with 20% glycerol and 0.025% ProClin 300; pH 7 | |
| P26450, P27986, Q63787 | |
| PIK3R1 | |
| Recombinant protein encompassing a sequence within the center region of human PI3 kinase p85 alpha. The exact sequence is proprietary. | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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