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Eurofins DiscoverX PI3 Kinase (p110δ/p85α) Human Protein

Product Code. p-7228248
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Quantity:
10 μg
250 μg
Unit Size:
10µg
250µg
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Product Code. 17340414

Brand: Eurofins DiscoverX 14604

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Description

Active complex of N-terminal His6-tagged recombinant, full-length, human p110δ and untagged, recombinant, full length, human p85α, for use in Kinase Assays.

Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. See MIM 602838. The class I PI3Ks display a broad phosphoinositide lipid substrate specificity and include p110-alpha (MIM 171834), p110-beta (MIM 602925), and p110-gamma (MIM 601232). p110-alpha and p110-beta interact with SH2/SH3-domain-containing p85 adaptor proteins (see MIM 171833) and with GTP-bound Ras.

GenBank NM_005026. The recombinant protein contains the amino acid substitution N253S with respect to this accession number. This conflict is reported inGenBank Y10055 and U57843. The residue coordinates in the native sequence are given / GenBank XM_043865

Specifications

Formulation mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.
Molecular Weight (g/mol) 121.6 kDa (P110δ) and 83.7 kDa (p85α)
Quantity 10 μg
Species Human
Recombinant Recombinant
Protein Tag N-terminal 6His / Untagged
Expression System Recombinant enzyme expressed in Sf21 insect cells
Protein Form Full-length
Purity or Quality Grade Combined ≥70%
Protein PI3 Kinase (p110δ/p85α)
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