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Invitrogen™ Phospho-YAP1 (Ser127) Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA517481
This item is not returnable.
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Description
It is not recommended to aliquot this antibody.
YAP (Yes-Associated Protein) is a founding member of the WW domain family of proteins, transcriptional co-activator and oncogene. Its gene is transcriptionally activated in squamous cell carcinoma cells. YAP can act both as a coactivator and corepressor and is the critical downstream regulatory target in the Hippo signaling pathway. The Hippo signaling pathway plays a pivotal role in organ size control and tumour suppression by restricting proliferation and promoting apoptosis. Also plays key roles in tissue tension, 3D tissue shape, cell proliferation, cell death, and cell migration. Mutations in the IRF5 gene results in coloboma.
Specifications
| Phospho-YAP1 (Ser127) | |
| Polyclonal | |
| Unconjugated | |
| YAP1 | |
| 65 kDa Yes-associated protein; AI325207; cb194; CH211-181P1.5-001; COB1; Protein yorkie homolog; sb:cb194; si:ch211-181p1.5; si:dkey-3b8.3; transcriptional coactivator YAP1; wu:fc18c04; yap; Yap1; YAP2; Yap65; Yes associated protein 1; Yes1 associated transcriptional regulator; yes-associated protein 1; yes-associated protein 2; yes-associated protein YAP65 homolog; yes-associated protein, 65 kDa; Yki; Yorkie; yorkie homolog; zgc:158380; zYAP | |
| Rabbit | |
| Protein A, Antigen affinity chromatography | |
| RUO | |
| 10413, 22601, 363014 | |
| -20°C | |
| Liquid |
| Western Blot | |
| 59.2 μg/mL | |
| 0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and no preservative; pH 7.5 | |
| P46937, P46938, Q2EJA0 | |
| YAP1 | |
| Synthetic phosphopeptide corresponding to residues surrounding pSer127 of human YAP. | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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