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Invitrogen™ Phospho-(Ser/Thr) ATM + ATR Substrate Monoclonal Antibody (G.770.10)

Product Code. 11382062
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Quantity:
100 μL
Unit Size:
100µL
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Product Code. Quantity unitSize
11382062 100 μL 100µL
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Product Code. 11382062 Supplier Invitrogen™ Supplier No. MA514872

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Description

Rabbit Monoclonal Antibody

It is not recommended to aliquot this antibody. This antibody is not cross-reactive with corresponding nonphosphorylated sequences or with other phospho-Ser/Thr-containing motifs. This antibody preferentially binds peptides and proteins that contain phospho-Ser/Thr preceded by Leu or similar hydrophobic amino acids at the -1 position and followed by Gln at the +1 position.

Ataxia telangiectasia mutated kinase (ATM) and ataxia telangiectasia and Rad3-related kinase (ATR) are related kinases that regulate cell cycle checkpoints and DNA repair. The identified substrates for ATM are p53, p95/NBS1, MDM2, Chk2, BRCA1, CtIP, 4E-BP1, and Chk1. The essential requirement for the substrates of ATM/ATR is S*/T*Q. Hydrophobic amino acids at positions -3 and -1, and negatively charged amino acids at position +1 are positive determinants for substrate recognition by these kinases. Positively charged residues surrounding the S*/T*Q are negative determinants for substrate phosphorylation. The complex phenotype of AT cells suggests that it likely has additional substrates.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-(Ser/Thr) ATM + ATR Substrate
Applications Western Blot
Classification Monoclonal
Clone G.770.10
Concentration 192 μg/mL
Conjugate Unconjugated
Formulation 0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and <0.02% sodium azide; pH 7.5
Gene Alias L(s/t)Q; SQ/TQ
Host Species Rabbit
Immunogen Synthetic phospho-ATM/ATR substrate peptides.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Target Species All species
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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