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Invitrogen™ Phospho-PDPK1 (Ser241) Recombinant Rabbit Monoclonal Antibody (PDK1S241-F7), APC, Invitrogen™
Rabbit Recombinant Monoclonal Antibody
Brand: Invitrogen™ MA537340
This item is not returnable.
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Description
PDPK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDPK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDPK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase, and the stimulation of glycogen synthesis. Because of the role that PDPK1 plays in insulin-induced glycogen synthesis and PKC activation, it is a potentially important target for metabolic drug research.
Specifications
| Phospho-PDPK1 (Ser241) | |
| Recombinant Monoclonal | |
| APC | |
| Pdpk1 | |
| 3-phosphoinositide dependent protein kinase 1; 3-phosphoinositide dependent protein kinase-1; 3-phosphoinositide-dependent protein kinase 1; 3-phosphoinositide-dependent protein kinase 2 pseudogene; HGNC:8809; hPDK1; isoenzyme 1; kinase isoenzyme 1; lipoamide; mPDK1; OTTHUMP00000174525; OTTHUMP00000205076; PDK1; PDPK1; PDPK2; PDPK2P; Pkb kinase; PkB kinase like gene 1; PkB-like 1; PRO0461; Protein kinase B kinase | |
| Rabbit | |
| Protein A/G | |
| RUO | |
| 5170 | |
| 4°C | |
| Liquid |
| Flow Cytometry | |
| PDK1S241-F7 | |
| PBS with 0.20% BSA and 0.09% sodium azide | |
| O15530 | |
| Pdpk1 | |
| A synthetic phospho-peptide corresponding to residues surrounding Ser241 of human phospho PDPK1. | |
| 10 Tests | |
| Primary | |
| Human | |
| Antibody | |
| IgG κ |
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