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Invitrogen™ Phospho-ERK5 (Thr219, Tyr221) Polyclonal Antibody
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Product Code. 17287333 Shop All Thermo Scientific Products
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Quantity:
100 μL
Unit Size:
100µL
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17287333 100 μL 100µL
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Product Code. 17287333 Supplier Invitrogen™ Supplier No. PA5114573

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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of ERK5 only when phosphorylated at Thr219+Tyr221.

MAPK7 (ERK5) serine/threonine kinase is a member of the MAP kinase family and is involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. MAPK7 is activated by mitogen-activated protein kinase 5 (MAP2K5/MEK5) and is involved in downstream signaling processes of various receptors. In response to extracelluar signals, MAPK7 translocates to the cell nucleus where it regulates gene expression by phosphorylating and activating different transcription factors. Gene deletion of MAPK7 in mice results in defective blood vessel and cardiac development leading to embryonic lethality. MAPK7 has been shown to be critical for endothelial function and maintenance of blood vessel integrity. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. ERK5 is expressed in many adult tissues, abundantly in heart, placenta, lung, kidney and skeletal muscle, but is not detectable in liver.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-ERK5 (Thr219, Tyr221)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide
Gene MAPK7
Gene Accession No. P0C865, Q13164, Q9WVS8
Gene Alias Big MAP kinase 1; BMK1; BMK-1; BMK1 kinase; BNhp-1; BNhp1 kinase; ERK4; ERK5; ERK-5; Erk5-T; extracellular signal regulated kinase 5; extracellular signal-regulated kinase 5; extracellular-signal-regulated kinase 5; MAP kinase 7; MAPK 7; Mapk7; mitogen activated protein kinase 7; mitogen-activated protein kinase 7; PRKM7
Gene Symbols MAPK7
Host Species Rabbit
Immunogen A synthesized peptide derived from human MAPK7(Accession Q13164), corresponding to amino acid residues around phosphorylated Tyr221.
Purification Method Sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 114509, 23939, 5598
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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