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Invitrogen™ Phospho-EEF2K (Ser366) Polyclonal Antibody
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Product Code. 16621045
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Quantity:
100 μL
Unit Size:
100µL
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16621045 100 μL 100µL
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Product Code. 16621045 Supplier Invitrogen™ Supplier No. PA5104591

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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of eEF2k only when phosphorylated at Ser366.

EEF2K is a highly conserved Serine/Threoning kinase in the calmodulin signaling pathway whose activity is increased in cancers including breast cancer. EEF2K (eukaryotic elongation factor 2 kinase) is a threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Up activation, by a variety of upstream kinases including AMPK or TRPM7, EEF2K phosphorylates the elongation factor EEF2 at a single site. Then, EEF2K renders EEF2 unable to bind ribosomes and inactive - in turn, the rate of protein synthesis is reduced.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-EEF2K (Ser366)
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene EEF2K
Gene Accession No. O00418, O08796, P70531
Gene Alias C86191; Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase; calcium/calmodulin-dependent eukaryotic elongation factor-2 kinase; calmodulin-dependent protein kinase III; EC 2.7.11.20; eEF-2 kinase; Eef2k; eEF-2K; EF2K; elongation factor 2 kinase; elongation factor-2 kinase; euk; eukaroytic elongation factor 2 kinase; eukaryotic elongation factor 2 kinase; eukaryotic elongation factor-2 kinase; HSU93850; kinase eEF2K; SMEF2K
Gene Symbols EEF2K
Host Species Rabbit
Immunogen A synthesized peptide derived from human EEF2K(Accession O00418), corresponding to amino acid residues around phosphorylated Ser366.
Purification Method sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 13631, 25435, 29904
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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