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Tocris Bioscience™ PF 3758309 Dihydrochloride, Tocris Bioscience™
Potent PAK4 inhibitor; orally available
Brand: Tocris Bioscience™ 6005/50
This item is not returnable.
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Description
PF 3758309 dihydrochloride is a potent PAK4 inhibitor (IC50 = 1.3 nM; Kd = 2.7 nM). Inhibits proliferation and anchorage-independent growth of a panel of tumor cell lines in vitro. Suppresses growth of human HCT116 and A549 tumor cell xenografts in mice. Orally available.Specifications
| PF 3758309 Dihydrochloride | |
| 50 mg | |
| Solid | |
| Bioactive Small Molecule |
| N-[(1S)-2-(Dimethylamino)-1-phenylethyl]-4,6-dihydro-6,6-dimethyl-3-[(2-methylthieno[3,2-d]pyrimidin-4-yl)amino]pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide dihydrochloride | |
| Soluble to 100mM in water and to 100mM in DMSO | |
| Off-white |
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