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Invitrogen™ PD-L1 Polyclonal Antibody

Product Code. 13452217
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Quantity:
100 μL
Unit Size:
100µL
Product Code. Quantity unitSize
13452217 100 μL 100µL
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Product Code. 13452217

Brand: Invitrogen™ PA528115

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Description

Rabbit Polyclonal Antibody

Recommended positive controls: A431, MDA-MB-231, MDA-MB-231 (24 μg/mL Tunicamycin treatment for 16 hr), MDA-MB-231, A549 (100 ng/mL IFN-gamma treatment for 48 hr), A431 (100 ng/mL IFN-gamma treatment for 48 hr). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a recently described B7 family member. To date, one specific receptor has been identified that can be ligated by PD-L1. This receptor, programmed death receptor 1 (PD-1), has been shown to negatively regulate T-cell receptor (TCR) signaling. Upon ligating its receptor, PD-L1 has been reported to decrease TCR-mediated proliferation and cytokine production. PD-L1 expression was found to be abundant on many murine and human cancers and could be further up-regulated upon IFN-gamma stimulation. Thus, PD-L1 might play an important role in tumor immune evasion.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PD-L1
Applications Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.97 mg/mL
Conjugate Unconjugated
Formulation PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene Cd274
Gene Accession No. Q9NZQ7
Gene Alias A530045L16Rik; B7 homolog 1; B7-H; B7h1; B7-H1; Cd274; CD274 antigen; CD274 molecule; PDCD1 ligand 1; Pdcd1l1; Pdcd1lg1; Pdl1; PD-L1; pdl-1; Programmed cell death 1 ligand 1; programmed death ligand 1; RGD1566211; sCD274; soluble CD274; soluble PD L1; sPD L1
Gene Symbols Cd274
Host Species Rabbit
Immunogen Synthetic peptide encompassing a sequence within the Intracellular domain of human PD-L1. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 29126
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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