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DiscoverX PathHunter™ U2OS SMO(W535L) MEM-EA Pharmacotrafficking Assay

Product Code. 17344169
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Quantity:
2 Vials
Unit Size:
2 ampoules
Product Code. Quantity unitSize
17344169 2 Vials 2 ampoules
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Product Code. 17344169

Brand: DiscoverX 930991C3

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Description

The PathHunter™ U2OS SMO(W535L) MEM-EA Pharmacotrafficking Assay measures pharmacochaperone-based stabilization of mutant SMO GPCR via detection of localization to the membrane. This cell line ships as two vials of cryopreserved cells.

The PathHunter™ U2OS SMO(W535L) MEM-EA Pharmacotrafficking Assay is a stable, engineered cell line for use in studying pharmacochaperones targeting SMO. This cell line enables assessment of chaperone-based stabilization of SMO(W535L) via detection of rescued membrane trafficking. This product uses EFC technology. The included cell line overexpresses PK-tagged mutant SMO(W535L), which is misfolded and retained in the ER. The cell line also expresses membrane-localized EA. When a pharmacochaperone stabilizes the mutant SMO, it is trafficked to the membrane, producing EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifications

Assay Entry Pharmacotrafficking
Cell Line U2OS
Format 2 vials
For Use With (Application) Cell Lines
Primary Agonist SANT-1
Quantity 2 Vials
Target Entry SMO(W535L)
Accession Number NM_005631.4
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