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Osimertinib, MedChemExpress

Product Code. 16481196
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16481196 200 mg 200mg
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16409367 5 mg 5mg
16401559 1 g 1g
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Product Code. 16481196 Supplier Medchem Express Supplier No. HY15772

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Description

MedChemExpress Osimertinib (AZD9291) is a covalent, orally active, irreversible, and mutant-selective EGFR inhibitor with an apparent IC50 of 12 nM against L858R and 1 nM against L858R/T790M, respectively. Osimertinib overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer.

Osimertinib (AZD9291) is a covalent, orally active, irreversible, and mutant-selective EGFR inhibitor with an apparent IC50 of 12 nM against L858R and 1 nM against L858R/T790M, respectively. Osimertinib overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer.

Specifications

Chemical Name or Material Osimertinib
CAS 1421373-65-0
Color Light Brown
Purity Grade Notes Research
Molecular Formula C28H33N7O2
Quantity 200 mg
Synonym AZD-9291 Mereletinib
Solubility Information DMSO : 62.5 mg/mL (125.10 mM; Need ultrasonic)
SMILES C=CC(NC1=CC(NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2)=C(OC)C=C1N(CCN(C)C)C)=O
Molecular Weight (g/mol) 499.61
Formula Weight 499.61
Percent Purity 99.51%
Grade Research
Physical Form Powder
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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