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Description
OAS3 is an interferon inducible protein that belongs to the 2-5A synthetase family, may play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis. OAS3 synthesizes preferentially dimeric 2′, 5′-oligoadenylate molecules. GTP can be an alternative substrate. OAS3 binds double-stranded RNA and polymerizes ATP into PPP(A2′P5′A)N oligomers, which activate the latent RNase L that, when activated, cleaves single-stranded RNAs. The protein is present at high level in placenta trophoblast.
Specifications
Specifications
| Antigen | OAS3 |
| Applications | Immunofluorescence, Western Blot, Immunocytochemistry, Immunohistochemistry (Paraffin) |
| Classification | Polyclonal |
| Concentration | 0.39 mg/mL |
| Conjugate | Unconjugated |
| Formulation | PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 |
| Gene | OAS3 |
| Gene Accession No. | Q9Y6K5 |
| Gene Alias | (2 5)oligo(A) synthase 3, 2 5 oligoadenylate synthase 3, 2 5A synthase 3, OAS3, p100, p100 OAS, p100OAS |
| Gene Symbols | OAS3 |
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Product Title
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