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Nirogacestat, MedChemExpress

Product Code. p-200099401
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Product Code. 16476656

Brand: Medchem Express HY15185

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Description

MedChemExpress Nirogacestat (PF-3084014) is a reversible, orally bioavailable, noncompetitive, and selective γ-secretase inhibitor with an IC50 of 6.2 nM. Inhibition of Notch signaling by Nirogacestat while minimizing gastrointestinal toxicity presents a promising approach for research of Notch receptor-dependent cancers.

Nirogacestat (PF-3084014) is a reversible, orally bioavailable, noncompetitive, and selective γ-secretase inhibitor with an IC50 of 6.2 nM. Inhibition of Notch signaling by Nirogacestat while minimizing gastrointestinal toxicity presents a promising approach for research of Notch receptor-dependent cancers.

Specifications

Chemical Name or Material Nirogacestat
CAS 1290543-63-3
Color White
Purity Grade Notes Research
Molecular Formula C27H41F2N5O
Quantity 100 mg
Synonym PF-3084014 PF-03084014
Solubility Information DMSO : 28.57 mg/mL (58.35 mM; Need ultrasonic) ∣H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)
SMILES FC1=C2C(CC[C@H](N[C@@H](CCC)C(NC3=CN(C(C)(C)CNCC(C)(C)C)C=N3)=O)C2)=CC(F)=C1
Molecular Weight (g/mol) 489.64
Formula Weight 489.64
Percent Purity 97.5%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-programmed cell death
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Research purposes only

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