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Nevanimibe hydrochloride, MedChemExpress

Product Code. 16499556
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Product Code. 16499556 Supplier Medchem Express Supplier No. HY100399A

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Description

MedChemExpress Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active and selective acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC50 of 9 nM. Nevanimibe hydrochloride inhibits ACAT2 with an EC50 of 368 nM. Nevanimibe hydrochloride induces cell apoptosis and has the potential for adrenocortical cancer.

Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active and selective acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC50 of 9 nM. Nevanimibe hydrochloride inhibits ACAT2 with an EC50 of 368 nM. Nevanimibe hydrochloride induces cell apoptosis and has the potential for adrenocortical cancer.

Specifications

Chemical Name or Material Nevanimibe hydrochloride
CAS 133825-81-7
Color White
Purity Grade Notes Research
Molecular Formula C27H40ClN3O
Quantity 50 mg
Synonym PD-132301 hydrochloride ATR101 hydrochloride
Solubility Information DMSO : 41.67 mg/mL (90.97 mM; Need ultrasonic) ∣H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)
SMILES O=C(NCC1(C2=CC=C(N(C)C)C=C2)CCCC1)NC3=C(C(C)C)C=CC=C3C(C)C.[H]Cl
Molecular Weight (g/mol) 458.08
Formula Weight 458.08
Percent Purity 98.07%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-programmed cell death
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Research purposes only

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