Nectin 1 (extracellular) Polyclonal Antibody, Invitrogen™

NECTIN1 is an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. NECTIN1 is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. NECTIN1 acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Further, NECTIN1 promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between NECTIN1 and NECTIN3, and between NECTIN1 and NECTIN4. NECTIN1 also has some neurite outgrowth-promoting activity. Mutations in the NECTIN1 gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing of NECTIN1 results in multiple transcript variants encoding proteins with distinct C-termini. Diseases associated with NECTIN1 include Cleft Lip/Palate-Ectodermal Dysplasia Syndrome and Zlotogora Syndrome.