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Invitrogen™ N4BP2L2 Polyclonal Antibody
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Product Code. 16658224
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Quantity:
100 μL
Unit Size:
100µL
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16658224 100 μL 100µL
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Product Code. 16658224 Supplier Invitrogen™ Supplier No. PA5101750

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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total N4BP2L2.

N4BP2L2 (NEDD4-binding protein 2-like 2), also known as PFAAP5 (phosphonoformate immuno-associated protein 5), is a 583 amino acid nuclear protein that potentially is involved in transcriptional regulation. N4BP2L2 is phosphorylated on Ser 199 in response to DNA damage, probably by ATM or ATR. Primarily expressed in bone marrow, N4BP2L2 is dramatically down-regulated after exposure to arsenic compounds, an event which precedes neutropenia. PFAAP5 interacts with both Gfi-1 and Neutrophil Elastase, two proteins that are implicated in neutropenia disorders. Defects in the gene encoding Neutrophil Elastase, ELA2, are the cause of cyclic haematopoiesis, which, with decreased numbers of circulating neutrophils, leads to an increased risk for opportunistic infection.
TRUSTED_SUSTAINABILITY

Specifications

Antigen N4BP2L2
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene N4BP2L2
Gene Accession No. Q8JZS6, Q92802
Gene Alias 2700092H06Rik; 92M18.3; CG005; CG016; N4BP2L2; NEDD4 binding protein 2 like 2; NEDD4 binding protein 2-like 2; NEDD4-binding protein 2-like 2; PFAAP5; phosphonoformate immuno-associated protein 5; Phosphonoformate immuno-associated protein 5 homolog; protein from BRCA2 region; zag1
Gene Symbols N4BP2L2
Host Species Rabbit
Immunogen A synthesized peptide derived from human N4BP2L2(Accession Q92802), corresponding to amino acid residues D358-R408.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10443, 381695
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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