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Invitrogen™ MSH3 Polyclonal Antibody
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Product Code. 17297523 Shop All Thermo Scientific Products
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Quantity:
100 μL
Unit Size:
100µL
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17297523 100 μL 100µL
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Product Code. 17297523 Supplier Invitrogen™ Supplier No. PA5114764

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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total MSH3.

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MSH3
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide
Gene MSH3
Gene Accession No. P13705, P20585
Gene Alias D13Em1; Divergent upstream protein; DNA mismatch repair protein Msh3; DUC1; DUG; DUP; hMSH3; Mismatch repair protein 1; MRP1; MSH3; mutS homolog 3; mutS homolog 3 (E. coli); protein repair-1; Protein repair-3; REP-1; Rep3; Rep-3
Gene Symbols MSH3
Host Species Rabbit
Immunogen A synthesized peptide derived from human MSH3(Accession P20585), corresponding to amino acid residues G110-F160.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 17686, 4437, 499505
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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