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Tocris Bioscience™ MRT 67307 dihydrochloride
GREENER_CHOICE

Salt inducible kinase (SIK) inhibitor

Brand:  Tocris Bioscience™ 5134/10

Encompass

Product Code. 15786625

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Description

Description

MRT 67307 dihydrochloride is a salt inducible kinase (SIK) inhibitor (IC50 values are 67, 250 and 430 nM for SIK2, SIK1 and SIK3 respectively). Also inhibits TBK1, MARK1-4, IKKε and NUAK1 (IC50 values are 19, 27-52, 160 and 230 nM respectively). Has no effect on IKKα or IKKβ. Induces IL-10 secretion and inhibits TNF-α and IL-6 secretion in bacterial LPS-stimulated macrophages. Also enhances IL-1-induced activation of NFκB-dependent gene transcription in mouse embryonic fibroblast (MEF) cells. Inhibits autophagy.
Specifications

Specifications

>98%
10 mg
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