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MRK-016, MedChemExpress

Product Code. 16499536
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Quantity:
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50mg
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Product Code. 16499536

Brand: Medchem Express HY100370

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Description

MedChemExpress MRK-016 is a selective, orally bioavailable inverse agonist of GABAA α5 receptor, with an EC50 of 3 nM for GABAA α5, and Kis of 0.83, 0.85, 0.77 and 1.4 nM for human GABAA α1β3γ2, GABAA α2β3γ2, GABAA α3β3γ2, and GABAA α5β3γ2, respectively; MRK-016 also readily penetrates the CNS.

MRK-016 is a selective, orally bioavailable inverse agonist of GABAA α5 receptor, with an EC50 of 3 nM for GABAA α5, and Kis of 0.83, 0.85, 0.77 and 1.4 nM for human GABAA α1β3γ2, GABAA α2β3γ2, GABAA α3β3γ2, and GABAA α5β3γ2, respectively

Specifications

Chemical Name or Material MRK-016
Physical Form Powder
CAS 342652-67-9
Color Off-White
Quantity 50 mg
Purity Grade Notes Research
Molecular Formula C17H20N8O2
For Use With (Application) Cancer-programmed cell death
Solubility Information DMSO : 50 mg/mL (135.73 mM; Need ultrasonic)
SMILES CN1N=CN=C1COC2=NN3C(C4=NOC(C)=C4)=NN=CC3=C2C(C)(C)C
Molecular Weight (g/mol) 368.39
Formula Weight 368.39
Percent Purity 98.29%
Grade Research
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Research purposes only

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