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Mitoxantrone, MedChemExpress

Product Code. 16446206
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Product Code. 16446206 Supplier Medchem Express Supplier No. HY13502

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Description

MedChemExpress Mitoxantrone is a potent topoisomerase II inhibitor. Mitoxantrone also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. Mitoxantrone induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone shows antitumor activity. Mitoxantrone also has anti-orthopoxvirus activity with EC50s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively.

Mitoxantrone is a potent topoisomerase II inhibitor. Mitoxantrone also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. Mitoxantrone induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone shows antitumor activity. Mitoxantrone also has anti-orthopoxvirus activity with EC50s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively.

Specifications

Chemical Name or Material Mitoxantrone
CAS 65271-80-9
Color Black
Purity Grade Notes Research
Molecular Formula C22H28N4O6
Quantity 100 mg
Synonym Mitozantrone NSC 301739
Solubility Information DMSO : 62.5 mg/mL (140.61 mM; Need ultrasonic)
SMILES O=C1C2=C(C(NCCNCCO)=CC=C2NCCNCCO)C(C3=C(O)C=CC(O)=C13)=O
Molecular Weight (g/mol) 444.48
Formula Weight 444.48
Percent Purity 98.0%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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