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Mitapivat, MedChemExpress

Product Code. 16488007
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Product Code. 16488007 Supplier Medchem Express Supplier No. HY12689

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Description

MedChemExpress Mitapivat (AG-348) is a potent, orally active, and allosteric activator of pyruvate kinase with an AC50 of 20 nM. Mitapivat (AG-348) increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes. Mitapivat (AG-348) has the potential for restoring the glycolytic pathway activity with PK deficiency.

Mitapivat (AG-348) is a potent, orally active, and allosteric activator of pyruvate kinase with an AC50 of 20 nM. Mitapivat (AG-348) increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes. Mitapivat (AG-348) has the potential for restoring the glycolytic pathway activity with PK deficiency.

Specifications

Chemical Name or Material Mitapivat
CAS 1260075-17-9
Color White
Purity Grade Notes Research
Molecular Formula C24H26N4O3S
Quantity 5 mg
Synonym AG-348
Solubility Information DMSO : 20.83 mg/mL (46.23 mM; ultrasonic and warming and heat to 60°C)
SMILES O=S(C1=C2N=CC=CC2=CC=C1)(NC3=CC=C(C(N4CCN(CC5CC5)CC4)=O)C=C3)=O
Molecular Weight (g/mol) 450.55
Formula Weight 450.55
Percent Purity 98.19%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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