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  4. Invitrogen™ Human MET (cMET), His Tag Recombinant Protein

Invitrogen™ Human MET (cMET), His Tag Recombinant Protein

Product Code. 10073172
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Quantity:
1 mg
10 μg
Unit Size:
10µg
1mg
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Product Code. 10073172

Brand: Invitrogen™ PV3588

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This item is not returnable. View return policy

Description

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Cytoplasmic.

MET (cMET) is a receptor-like tyrosine kinase whose dysregulation has been linked to many types of human malignancies. After activation of the ligand, MET interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3. There interactions lead to the activation of signaling cascades including RAS-ERK, PI3, kinase-AKT, and PLCgamma-PKC. MET plays a role in embryonic development including gastrulation, development of muscles and neurons, angiogenesis, and kidney formation. It also plays a role in adults including wound healing, organ regeneration, and tissue remodeling. MET has been linked to cancers including gastric, renal, and breast; therefore, making it a target for cancer therapeutics and diagnostic testing.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P08581
Concentration See Label
For Use With (Application) Kinase Assay
Formulation 20mM tris with 0.5mM EDTA, 100mM NaCl, 2mM DTT, 50% glycerol, 0.05% Triton X-100 and no preservative; pH 7.5
Gene ID (Entrez) 4233
Molecular Weight (g/mol) 53.7 kDa
Name Human MET (cMET), His Tag
pH Range 7.5
Purification Method Purified
Quantity 1 mg
Storage Requirements -80°C, Avoid Freeze/Thaw Cycles
Regulatory Status RUO
Gene Alias AI838057; AUTS9; bHLHe59; CG1705; CG1705-PA; CG1705-PB; cmet; c-met; c-met proto-oncogene; c-Met receptor tyrosine kinase; c-Met/HGF receptor; D249; DFNB97; Dmel\CG1705; Dmel_CG1705; DmMet; EC 2.7.10.1; Hepatocyte growth factor receptor; HGF; HGF receptor; HGF receptor c-Met; HGF/SF receptor; HGFR; HGF-SF receptor; juvenile hormone resistance; met; met proto-oncogene; met proto-oncogene (hepatocyte growth factor receptor); met proto-oncogene tyrosine kinase; MET proto-oncogene, receptor tyrosine kinase; Met/Met1; Met; protein tyrosin kinase; methoprene tolerant; Methoprene-tolerant; Methoprene-tolerant protein; Met-PA; Met-PB; Mett; oncogene MET; Par4; Proto-oncogene c-Met; RCCP2; resistance (1) juvenile H; resistance to juvenile hormone; Rst(1)JH; sc MET; scatter factor receptor; SF receptor; soluble c met; tyrosine-protein kinase Met
Common Name c-Met
Gene Symbol MET
KinaseFamily MET (HGFR) Kinase Family
Protein Length 956-1390
Product Type Protein
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag His-tag
Sequence 956-1390
Content And Storage -80°C, Avoid Freeze/Thaw Cycles
Kinase Group Tyrosine Kinases
Shipping Condition Dry Ice
Expression System Baculovirus
Protein Form Cytoplasmic
Form Liquid
Research Category Drug Development
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