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Masitinib mesylate, MedChemExpress

Product Code. 16470097
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Product Code. 16470097 Supplier Medchem Express Supplier No. HY10209A

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Description

MedChemExpress Masitinib mesylate (AB-1010 mesylate) is a potent, orally bioavailable, and selective inhibitor of c-Kit (IC50=200 nM for human recombinant c-Kit). It also inhibits PDGFRα/β (IC50s=540/800 nM), Lyn (IC50= 510 nM for LynB), Lck, and, to a lesser extent, FGFR3 and FAK. Masitinib mesylate (AB-1010 mesylate) has anti-proliferative, pro-apoptotic activity and low toxicity.

Masitinib mesylate (AB-1010 mesylate) is a potent, orally bioavailable, and selective inhibitor of c-Kit (IC50=200 nM for human recombinant c-Kit). It also inhibits PDGFRα/β (IC50s=540/800 nM), Lyn (IC50= 510 nM for LynB), Lck, and, to a lesser extent, FGFR3 and FAK. Masitinib mesylate (AB-1010 mesylate) has anti-proliferative, pro-apoptotic activity and low toxicity.

Specifications

Chemical Name or Material Masitinib mesylate
CAS 1048007-93-7
Color White
Purity Grade Notes Research
Molecular Formula C29H34N6O4S2
Quantity 50 mg
Synonym AB-1010 mesylate
Solubility Information DMSO : ≥ 30 mg/mL (50.44 mM)
SMILES O=C(NC1=CC=C(C(NC2=NC(C3=CC=CN=C3)=CS2)=C1)C)C4=CC=C(CN5CCN(CC5)C)C=C4.CS(=O)(O)=O
Molecular Weight (g/mol) 594.75
Formula Weight 594.75
Percent Purity 99.76%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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