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  4. Invitrogen™ Human MAP4K4 (HGK), GST Tag Recombinant Protein

Invitrogen™ Human MAP4K4 (HGK), GST Tag Recombinant Protein

Product Code. 11593507
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Quantity:
1 mg
10 μg
100 μg
Unit Size:
100µg
10µg
1mg
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Product Code. 11593507

Brand: Invitrogen™ PV3687

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Description

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Recombinant, Catalytic Domain.

MAP4K4 (HGK) is a serine/threonine kinase which plays an important role in stress-activated MAPK core signaling pathways, the response to environmental stress and cytokines such as TNF-alpha. It appears to act upstream of the JUN N-terminal pathway. This protein is thought to interact with the SH3 domain of the adapter proteins Nck. HGK binds, via its CNH regulatory domain, to the N-terminal region of SPG3A. Expression appears to be ubiquitous, expressed in all tissue types examined. Isoform 5 appears to be more abundant in the brain, and isoform 4 is predominant in the liver, skeletal muscle and placenta.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number O95819
Concentration See Label
For Use With (Application) Kinase Assay
Formulation 50mM tris with 50% glycerol, 2mM DTT, 0.02% Triton X-100, 0.5mM EDTA, 150mM NaCl and no preservative; pH 7.5
Gene ID (Entrez) 9448
Molecular Weight (g/mol) 65 kDa
Name Human MAP4K4 (HGK), GST Tag
pH Range 7.5
Purification Method Purified
Quantity 10 μg
Storage Requirements -80°C, Avoid Freeze/Thaw Cycles
Regulatory Status RUO
Gene Alias 9430080K19Rik; AU043147; AU045934; AW046177; epididymis secretory protein Li 31; FLH21957; FLJ10410; FLJ20373; FLJ90111; HEL-S-31; hepatocyte progenitor kinase-like/germinal center kinase-like kinase; HGK; HPK/GCK-like kinase HGK; KIAA0687; Map4k4; MAPK/ERK kinase kinase kinase 4; MEK kinase kinase 4; MEKKK 4; MEKKK4; mitogen activated protein kinase kinase kinase kinase 4; mitogen-activated protein kinase kinase kinase kinase 4; NCK interacting kinase; nck-interacting kinase; NIK; Ste20 group protein kinase HGK
Common Name HGK
Gene Symbol MAP4K4
Protein Length 1-328
Product Type Protein
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag GST-tag
Sequence 1-328
Content And Storage -80°C, Avoid Freeze/Thaw Cycles
Assay Entry Biochemical phospho-specific activity (no antibody), Biochemical terbium phospho-specific activity, Biochemical binding/kinetic
Kinase Group Ser⁄Thr Kinases: STE Group
Shipping Condition Dry Ice
System Compatibility LanthaScreen™ Antibody, LanthaScreen™ Substrate, Zin-LYTE™, Omnia™ Bulk Substrate
Target Entry MAP4K4
Expression System Insect cells
Protein Family Kinases & Inhibitors
Protein Form Recombinant, Catalytic Domain
Form Liquid
Protein Subtype Serine/Threonine Kinases
Research Category Drug Discovery: Signal Transduction
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