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LY2886721, MedChemExpress

Product Code. 16468277
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Product Code. 16468277

Brand: Medchem Express HY13240

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Description

MedChemExpress LY2886721 is a potent, selective and orally active beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 20.3 nM for recombinant human BACE1. LY2886721 is selectivity against cathepsin D, pepsin, and renin, but lacking selectivity against BACE2 (IC50 of 10.2 nM). LY2886721 can across blood-brain barrier and has the potential for Alzheimer's disease treatment.

LY2886721 is a potent, selective and orally active beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 20.3 nM for recombinant human BACE1. LY2886721 is selectivity against cathepsin D, pepsin, and renin, but lacking selectivity against BACE2 (IC50 of 10.2 nM). LY2886721 can across blood-brain barrier and has the potential for Alzheimer's disease treatment.

Specifications

Chemical Name or Material LY2886721
CAS 1262036-50-9
Color White
Purity Grade Notes Research
Molecular Formula C18H16F2N4O2S
Quantity 5 mg
Solubility Information DMSO : 20 mg/mL (51.23 mM; Need ultrasonic) ∣H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)
SMILES FC1=CN=C(C=C1)C(NC2=CC=C(C([C@@]34[C@]([H])(CSC(N)=N4)COC3)=C2)F)=O
Molecular Weight (g/mol) 390.41
Formula Weight 390.41
Percent Purity 99.42%
Grade Research
Physical Form Solid
For Use With (Application) Neuroscience-Neurodegeneration
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Research purposes only

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