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Invitrogen™ LRRK2 (WT) Recombinant Protein

Product Code. 15393806
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100 μg
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10µg
1mg
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15393806 100 μg 100µg
15383806 10 μg 10µg
15303816 1 mg 1mg
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Product Code. 15393806 Supplier Invitrogen™ Supplier No. A15198

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Description

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. This full-length, purified and active wild-type LRRK2 protein may be useful in research to better understand the native protein, unaffected by mutations, as well as to explore the mechanisms underlying the disease. Increase disease relevance by interrogating a purified and active full-length LRRK2 protein Uncover novel compounds or hits specific to the full-length form Advance Parkinson's research using the full-length protein and validated assays Related Links:LRRK2 Tools for Advancing Parkinson's Disease ResearchLanthaScreen™ Kinase Activity AssayLanthaScreen™ Eu Kinase Binding Assay Protein Form: Recombinant, Full Length.

LRRK2 (Leucine Rich Repeat Kinase 2) is a Protein Coding gene. Diseases associated with LRRK2 include Parkinson Disease 8, Autosomal Dominant and Hereditary Late-Onset Parkinson Disease. Among its related pathways are Signaling by PTK6 and ncRNAs involved in Wnt signaling in hepatocellular carcinoma. Gene Ontology (GO) annotations related to LRRK2 (G2019S Mutant) include protein homodimerization activity and transferase activity, transferring phosphorus-containing groups. An important paralog of LRRK2 (G2019S Mutant) is TNNI3K. Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene, which codes for a multidomain protein kinase, are considered the most common genetic cause of late-onset autosomal-dominant Parkinson's disease.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number Q5S007
Concentration See Label
For Use With (Application) Kinase Assay
Formulation Proprietary buffer with no preservative
Gene ID (Entrez) 120892
Molecular Weight (g/mol) 288 kDa
Name LRRK2 (WT)
Purification Method Purified
Quantity 100 μg
Storage Requirements -80°C, Avoid Freeze/Thaw Cycles
Regulatory Status RUO
Gene Alias LRRK2
Common Name LRRK2 (WT)
Gene Symbol LRRK2
KinaseFamily LRRK Kinase Family
Product Type Protein
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag DYKDDDDK-tag
Sequence Full length
Content And Storage -80°C, Avoid Freeze/Thaw Cycles
Expression System Baculovirus
Protein Family Kinases & Inhibitors
Protein Form Recombinant, Full Length
Form Liquid
Research Category Neurobiology
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