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Lestaurtinib, MedChemExpress

Product Code. 16490578
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5 mg
Unit Size:
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Product Code. 16490578 Supplier Medchem Express Supplier No. HY50867

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Description

MedChemExpress Lestaurtinib (CEP-701) is an orally active and selective RPTKs (receptor protein tyrosine kinase) inhibitor, competitively inhibits ATP binding to the TrkA/B/C domain. Lestaurtinib inhibits RPTKs phosphorylation, with IC50s of 2, 25 and 0.9 nM for FLT3, TrkA and JAK2, respectively. Lestaurtinib induces apoptosis and cycle arrest, also can inhibit growth of tumor.

Lestaurtinib (CEP-701) is an orally active and selective RPTKs (receptor protein tyrosine kinase) inhibitor, competitively inhibits ATP binding to the TrkA/B/C domain. Lestaurtinib inhibits RPTKs phosphorylation, with IC50s of 2, 25 and 0.9 nM for FLT3, TrkA and JAK2, respectively. Lestaurtinib induces apoptosis and cycle arrest, also can inhibit growth of tumor.

Specifications

Chemical Name or Material Lestaurtinib
CAS 111358-88-4
Color White
Purity Grade Notes Research
Molecular Formula C26H21N3O4
Quantity 5 mg
Synonym CEP-701 KT-5555
Solubility Information DMSO : 50 mg/mL (113.78 mM; Need ultrasonic)
SMILES O=C(NC1)C2=C1C3=C(C4=C52)N(C6=C3C=CC=C6)[C@@]([C@@](O)(CO)C7)(C)O[C@H]7N4C8=C5C=CC=C8
Molecular Weight (g/mol) 439.46
Formula Weight 439.46
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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